For the first time, scientists have created a comprehensive brain map of changes in gene expression from prenatal development through adulthood, creating a reference point from which to understand the development of brain pathologies such as schizophrenia.
Joel Kleinman, M.D., Ph.D., recipient of the Brain and Behavior Foundation’s 2011 Lieber Prize for Schizophrenia Research, led the research, which for the first time tracked the entire brain (not just a single region) over the entire human developmental cycle.
“Ultimately, we want to find targets for treatment,” Kleinman said. “This lets you take the first step in understanding how genetic variants increase risk for any brain disease.”
The results were published in Nature Magazine, and all the data from the research has been made freely available online for use by reseachers throughout the world.
Read more about this groundbreaking work on the Schizophrenia Research Forum.